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Inhibition of NF-κB by Pyrrolidine Dithiocarbamate Prevents the Inflammatory Response in a Ligature-Induced Peri-Implantitis Model: A Canine Study.

Cell. Physiol. Biochem.. 2018;

HeChun-Yan，JiangLi-Peng，WangCheng-Yue，Zhan

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	… USA), which was subsequently blocked with 5% non-fat milk powder at room temperature for 1h and then incubated with TLR4 (1: 1000, Abcam Inc., Cambridge, MA, USA, ab22048) and beta-actin (β-actin) primary antibodies (1: 2000, A00702, GenScript, Piscataway, NJ, USA …

摘要

The roles of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) in peri-implantitis are unclear. Here， we used a canine model of peri-implantitis to explore the effects of inhibiting NF-κB with pyrrolidine dithiocarbamate (PDTC) on the inflammatory response in ligature-induced peri-implantitis.