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CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.

Mol. Cell. 2017; 
Lin Ran,Mo Yan,Zha Haihong,Qu Zhipeng,Xie Pancheng,Zhu Zheng-Jiang,Xu Ying,Xiong Yue,Guan Kun-L
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摘要

In addition to responding to environmental entrainment with diurnal variation, metabolism is also tightly controlled by cell-autonomous circadian clock. Extensive studies have revealed key roles of transcription in circadian control. Post-transcriptional regulation for the rhythmic gating of metabolic enzymes remains elusive. Here, we show that arginine biosynthesis and subsequent ureagenesis are collectively regulated by CLOCK (circadian locomotor output cycles kaput) in circadian rhythms. Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthe... More

关键词

acetylation,circadian,metabolism,ureagen