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Transient increase in VEGF-A leads to cardiac tube anomalies and increased risk of congenital heart malformations

Anat Rec (Hoboken). 2021-02; 
Graham Rykiel, MacKenzie Gray, Brenda Rongish, Sandra Rugonyi
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Recombinant Proteins … For both early and late stage analyses we treated HH8 (28-30 hours of incubation; just prior to heart tube formation) quail embryos in ovo with recombinant human VEGF165 (rhVEGF165; GenScript®, Z02689) or a control solution … Get A Quote

摘要

Vascular endothelial growth factor (VEGF) plays a critical role during early heart development. Clinical evidence shows that conditions associated with changes in VEGF signaling in utero are correlated with an increased risk of congenital heart defects (CHD) in newborns. However, how malformations develop after abnormal VEGF exposure is unknown. During embryogenesis, a primitive heart, consisting of an endocardial tube enveloped by a myocardial mantle, is the first organ to function. This tubular heart ultimately transforms into a four-chambered heart. To determine how a transient increase in VEGF prior to heart tube formation affects heart development leading to CHD, we applied exogenous VEGF or a control (veh... More

关键词

VEGF, avian embryo, cardiac development, cardiac malformation, congenital heart disease, heart tube formation, in ovo protocol