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BASI, A Potent Small Molecular Inhibitor, Inhibits Glioblastoma Progression by Targeting microRNA-mediated β-Catenin Signaling.

CNS Neurosci Ther.. 2014-05;  :2014-05
Shi ZD, Qian XM, Zhang JX, Han L, Zhang KL, Chen LY, Zhou X, Zhang JN, Kang CS. Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin, China.
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摘要

BACKGROUND AND AIMS:The nuclear localization of β-catenin, a mediator of canonical Wnt signaling, has been indicated in a variety of cancers and is frequently related to tumor progression and metastasis. Therefore, targeting β-catenin is an attractive therapeutic strategy for cancers.METHODS:Herein, we identified a natural, small molecule inhibitor of β-catenin signaling, BASI, and evaluated its therapeutic efficacy both in vitro and in orthotopic mouse models of glioma.RESULTS:BASI significantly suppressed proliferation and invasion and induced apoptosis in glioblastoma cells and resulted in the remarkable attenuation of orthotopic tumor growth in vivo. Furthermore, we found that BASI altered th... More

关键词

BASI ; Glioblastoma; Inhibitor; microRNA; β-Catenin