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Kinetics of Immune Cell Infiltration in Vaccinia Virus Keratitis.

Invest Ophthalmol Vis Sci.. 2010-09;  51(9):4541 - 4548
Sharon Altmann, Megan Toomey, Brittany Nesbit, Kim McIntyre, Jill Covert, Richard Redd Dubielzig, Gary Leatherberry, Elizabeth Adkins, Christopher J. Murphy, and Curtis R. Brandt. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
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摘要

PURPOSE: Vaccinia virus keratitis leading to blindness is a severe complication of smallpox vaccination. The clinical manifestations of vaccinia virus keratitis are similar to those of herpes simplex virus keratitis, a well-studied immunopathologic disease. Vaccinia virus keratitis is likely to involve an immunopathologic component, but little is known about the pathogenesis of the disease. The goal of this study was to determine type and kinetics of immune cell infiltration in the cornea during vaccinia virus keratitis. METHODS: Rabbit eyes were trephined and inoculated with 1x10(5) pfu of the Dryvax strain of the vaccinia virus. On days 2, 4, 7, 10, 14, and 28 after infection, the animals were scored for cl... More

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