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The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.

Biochim Biophys Acta.. 2016-02; 
Zhang HT, Zeng LF, He QY, Tao WA, Zha ZG, Hu CD.
Products/Services Used Details Operation
... actin (Cell Signaling Technology, 8H10D10), anti-PRMT5 (Millipore, 07–405), anti-CHIP (Santa Cruz, G-2 sc-133,066), anti-FLAG M2 (Cell Signaling Technology, 9A3), anti-HA (Cell Signaling Technology, 6E2), anti-GST (BD Biosciences), and anti-Myc (GenScript, A00704-100 ...

摘要

Protein arginine methyltransferase 5 (PRMT5) is an important member of the protein arginine methyltransferase family that regulates many cellular processes through epigenetic control of target gene expression. Because of its overexpression in a number of human cancers and its essential role in cell proliferation, transformation, and cell cycle progression, PRMT5 has been recently proposed to function as an oncoprotein in cancer cells. However, how its expression is regulated in cancer cells remains largely unknown. We have previously demonstrated that the transcription of PRMT5 can be negatively regulated by the PKC/c-Fos signaling pathway through modulating the transcription factor NF-Y in prostate cancer cell... More

关键词

CHIP; Chaperone; E3 ubiquitin ligase; PRMT5; Prostate cancer; Ubiquitination