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HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs.

Mech. Ageing Dev.. 2018-01; 
CohenJustin,D'AgostinoLuca,TuzerFerit,TorresCla
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… Signaling Technology, Danvers, MA), HMGB2 (LS-B4355(3D2), monoclonal, LSBio, Seattle, WA), phosphorylated (9570 s) and total eNOS (9572 s) both polyclonal, (Cell Signaling Technology, Danvers, MA), β-actin (A00702 (2D1D10), monoclonal, Genscript, Piscataway, NJ) …

摘要

Developments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable disease. Despite this advance, patients suffer from co-morbidities best described as an accelerated aging phenotype. A potential contributor is cellular senescence, an aging-associated growth arrest, which has already been linked to other HIV co-morbidities such as lipodystrophies and osteoporosis in response to antiretroviral drugs. We have previously demonstrated that astrocytes senescence in response to antiretroviral drugs. As endothelial cells play a c... More

关键词

Astrocyte senescence,HIV premature aging,HIV-associated neurocognitive disorders,HUVEC senescence,Highly active antiretroviral the