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A Bacterial Type III Effector Targets the Master Regulator of Salicylic Acid Signaling NPR1 to subvert Plant Immunity.

Cell Host Microbe.. 2017-12; 
Chen H, Chen J, Li M, Chang M, Xu K, Shang Z, Zhao Y, Palmer I, Zhang Y, McGill J, Alfano JR, Nishimura MT, Liu F, Fu ZQ.
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摘要

Most plant bacterial pathogens rely on type III effectors to cause diseases. Although it is well known that the plant hormone salicylic acid (SA) plays an essential role in defense, whether the master regulator of SA signaling, NPR1, is targeted by any plant pathogen effectors is unknown. SA facilitates the reduction of cytosolic NPR1 oligomers into monomers, which enter the nucleus and function as transcriptional coactivators of plant defense genes. We show that SA promotes the interaction between the Pseudomonas syringae type III effector AvrPtoB and NPR1. In the presence of SA, AvrPtoB mediates the degradation of NPR1 via the host 26S proteasome in a manner dependent on AvrPtoB's E3 ligase activity. Intrigui... More

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