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Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression

Brain Behav. Immun.. 2017-05; 
HutsonLee W, LebonvilleChristina L, JonesMeghan E, FuchsRita A, LysleDona
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… Human recombinant interleukin-1 receptor antagonist (IL-1Ra; Genscript, Piscataway, NJ, USA; Catalog No: Z00367) was reconstituted in 0.9% sterile saline to a final concentration of 2.5 μg/μL, aliquoted, and then stored at −20 °C. 2.3. Surgical procedures …

摘要

Heroin administration suppresses the production of inducible nitric oxide (NO), as indicated by changes in splenic inducible nitric oxide synthase (iNOS) and plasma nitrate/nitrite. Since NO is a measure of host defense against infection and disease, this provides evidence that heroin can increase susceptibility to pathogens by directly interacting with the immune system. Previous research in our laboratory has demonstrated that these immunosuppressive effects of heroin can also be conditioned to environmental stimuli by repeatedly pairing heroin administration with a unique environmental context. Re-exposure to a previously drug-paired context elicits immunosuppressive effects similar to heroin administrat... More

关键词

Basolateral amygdala,Heroin,IL-1,IL-1 receptor antagonist,Immune conditioning, opioid,Learning,Nitric o