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Porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis.

Biol. Reprod.. 2018; 
ZhangLiang,WangZhenyu,ZhangJie,LuoXiaomao,DuQian,ChangLingling,ZhaoXiaomin,HuangYong,TongD
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China), α-Tublin (catalog number A01410, Genscript, Biotech Co., Ltd, China), GAPDH (catalog number A01622, Genscript Biotech Co.) and Histone H3 (catalog number 9715, Cell Signaling Technology)

摘要

Porcine parvovirus (PPV) is a major virus that leads to fetal death in swine. However, the effects of PPV infection on sows are poorly understood. The aim of this study was to investigate the effects of PPV on porcine steroidogenic luteal cells (SLCs) survival and functions and underlying mechanisms. In vivo experiment results showed that artificial infection of PPV significantly reduced the concentration of serum progesterone and induced histopathological lesions and SLCs apoptosis in porcine corpora luteum. In in vitro cultured primary porcine SLCs, PPV could infect and replicate in SLCs and induced SLCs apoptosis through mitochondria, but not the death receptor, mediated apoptosis pathway. Meanwhile�... More

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