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Visualizing the Regulation of Hydroxyl Radical Level by Superoxide Dismutase via a Specific Molecular Probe.

Anal. Chem.. 2018; 
ZengLingyu,XiaTian,HuWei,ChenShiyu,ChiSiyu,LeiYidi,LiuZhi
Products/Services Used Details Operation
Interferon-gamma (IFN-γ) was obtained from GenScript (Lot # Z02916).

摘要

Hydroxyl radical (·OH), as the most deleterious reactive oxygen species, is believed to be the etiological agent for many diseases and aging. An altered ·OH level has been confirmed in certain types of superoxide dismutase (SOD) mutation, but the regulation of ·OH by SOD in situ is still controversial or unclear because of the lack of effective tools to detect ·OH in the biological environment. Herein we report the first two-photon excitable molecular probe (P2) for ·OH, which is able to track the subtle fluctuation of ·OH level both in vitro and in vivo with high sensitivity and specificity. The probe was successfully applied to visualize ·OH variations in a variety of SOD1-involved biological p... More

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