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Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats.

Physiol Rep. 2015; 
Cox-YorkKimberly A,SheflinAmy M,FosterMichelle T,GentileChristopher L,KahlAmber,KochLauren G,BrittonSteven L,WeirTiffa
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Proteins, Expression, Isolation and Analysis … Plasma endotoxin Plasma endotoxin (ET) was determined using ToxinSensor L00350 (GenScript, Piscataway, NJ) as per manufacturer's protocol All steps were carried out in ET‐free glass and plasticware using ET‐free water and reagents … Get A Quote

摘要

The increased risk for cardiometabolic disease with the onset of menopause is widely studied and likely precipitated by the decline in endogenous estradiol (E2), yet the precise mechanisms are unknown. The gut microbiome is involved in estrogen metabolism and has been linked to metabolic disease, suggesting its potential involvement in the postmenopausal phenotype. Furthermore, menopause-associated risk factors, as well as gut ecology, are altered with exercise. Therefore, we studied microbial changes in an ovariectomized (OVX vs. Sham) rat model of high (HCR) and low (LCR) intrinsic aerobic capacity (n = 8-10/group) in relation to changes in body weight/composition, glucose tolerance, and liv... More

关键词

Aerobic capacity,gut microbiota,menop