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The KSHV ORF34 protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.

J. Virol.. 2019-06; 
HaqueMuzammel,Kousoula
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Monoclonal Antibody Services Cell lysates were prepared at specific times post induction and immunoprecipitated with anti-Myc antibody (GenScript, NJ).. Mouse monoclonal antibodies to Flag (A00187) and anti-cMyc (A00704) were from GenScript (Piscataway, NJ)... Cleared lysates were mixed withsample buffer, heated at 92 ℃ for 5 min, separated through 4-20% SurePAGE gel (M00656,GenScript, NJ) Get A Quote

摘要

Hypoxia and hypoxia inducible factors (HIFs) play important roles in the Kaposi's sarcoma-associated herpesvirus (KSHV) life cycle. KSHV is the causative agents of Kaposi's sarcoma (KS) and other AIDS related malignancies. Kaposi's sarcoma is a highly vascular tumor, which preferentially develops in the lower extremities of the body where blood vessels are often poorly oxygenated. The main cellular responses to hypoxia are mediated mainly by two isoforms of HIF, HIF-1α and HIF-2α. Both HIF-1α and HIF-2α have common as well as distinct functions, although they are similar in structure and function. Previously, we showed that the KSHV ORF34 protein binds HIF-1α and facilitates its degradation through... More

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