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Three Genes Define a Bacterial-Like Arsenic Tolerance Mechanism in the Arsenic Hyperaccumulating Fern Pteris vittata.

Curr Biol. 2019-05; 
CaiChao,LanmanNadia A,WithersKelley A,DeLeonAlyssa M,WuQiong,GribskovMichael,SaltDavid E,BanksJo
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Gene Synthesis … Tetro cDNA Synthesis Kit, Bioline, Cat# BIO-65042. PowerUp SYBR Green Master Mix, Applied Biosystems, Cat# A25742. HisPur Ni-NTA Resin, Thermo Scientific, Cat# 88221. Recombinant Enterokinase (rEK), GenScript, Cat# Z03004. human GAPDH, Sigma-Aldrich, Cat# G6019 … Get A Quote

摘要

Arsenic is a carcinogenic contaminant of water and?food and a growing threat to human health in?many regions of the world. This study focuses on the fern Pteris vittata (Pteridaceae), which is?extraordinary in?its ability to tolerate and hyperaccumulate very?high levels of arsenic that would kill?any other plant or?animal outside the Pteridaceae. Here, we?use RNA-seq to identify three?genes (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (PvGAPC1), ORGANIC CATION TRANSPORTER 4 (PvOCT4), and GLUTATHIONE S-TRANSFERASE (PvGSTF1) that are highly upregulated by arsenic and are necessary for arsenic tolerance, as demonstrated by RNAi. The proteins encoded by these genes have unexpected properties: PvGAPC1 has an ... More

关键词

GAPDH,GST,OCT4,Pteris vittata,arsenic,