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Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.

Neuron. 2019-06; 
NakagawaNaoki,PlestantCharlotte,Yabuno-NakagawaKeiko,LiJingjun,LeeJanice,HuangChu-Wei,LeeAmelia,KrupaOleh,AdhikariAditi,ThompsonSuriya,RhynesTamille,ArevaloVictoria,SteinJason L,MolnárZoltán,BadacheAli,Anto
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Catalog Antibody The following primary antibodies were used: acetylated tubulin (mouse, T6793, Sigma-Aldrich), b-actin (mouse, 8226, Abcam), CAMSAP2 (rabbit, 17880-1-AP, Proteintech), glutamylated tubulin (rabbit, AB3201, Millipore), HA (mouse, A01244, GenScript), Get A Quote

摘要

Polarized, non-overlapping, regularly spaced, tiled organization of radial glial cells (RGCs) serves as a framework to generate and organize cortical neuronal columns, layers, and circuitry. Here, we show that mediator of cell motility 1 (Memo1) is a critical determinant of radial glial tiling during neocortical development. Memo1 deletion or knockdown leads to hyperbranching of RGC basal processes and disrupted RGC tiling, resulting in aberrant radial unit assembly and neuronal layering. Memo1 regulates microtubule (MT) stability necessary for RGC tiling. Memo1 deficiency leads to disrupted MT minus-end CAMSAP2 distribution, initiation of aberrant MT branching, and altered polarized trafficki... More

关键词

MADM,Memo1,autism,corticogenesis,microtubule minus end,progenitors,radial