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Human antibody-based chemically induced dimerizers for cell therapeutic applications.

Nat. Chem. Biol.. 2018; 
Hill Zachary B,Martinko Alexander J,Nguyen Duy P,Wells Jam
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Recombinant Proteins .... (GenScript mouse mAb, A01738). CRISPRa-mediated luciferase assay. For CRISPRa-mediated....-AviTag antibody (GenScript mouse mAb, A01738) Myc-Tag Mouse mAb Alexa Fluor647 conjugate (Cell Get A Quote

摘要

Chemically induced dimerizers (CIDs) have emerged as one of the most powerful tools for artificially regulating signaling pathways in cells; however, currently available CID systems lack the properties desired for use in regulating cellular therapies. Here, we report the development of human antibody-based chemically induced dimerizers (AbCIDs) from known small-molecule-protein complexes by selecting for synthetic antibodies that recognize the chemical epitope created by the bound small molecule. We demonstrate this concept by generating three antibodies that are highly selective for the BCL-xL-ABT-737 complex compared to BCL-xL alone. We show the potential of AbCIDs for application in regulating human cell... More

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