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Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance.

Sci Signal. 2017; 
Wu Wei,Shi Fubiao,Liu Dianxin,Ceddia Ryan P,Gaffin Robert,Wei Wan,Fang Huafeng,Lewandowski E Douglas,Collins Sh
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摘要

In addition to controlling blood pressure, cardiac natriuretic peptides (NPs) can stimulate lipolysis in adipocytes and promote the "browning" of white adipose tissue. NPs may also increase the oxidative capacity of skeletal muscle. To unravel the contribution of NP-stimulated metabolism in adipose tissue compared to that in muscle in vivo, we generated mice with tissue-specific deletion of the NP clearance receptor, NPRC, in adipose tissue ( ) or in skeletal muscle ( ). We showed that, similar to null mice, mice, but not mice, were resistant to obesity induced by a high-fat diet. mice exhibited increased energy expenditure, improved insulin sensitivity, and increased glucose uptake into... More

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