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C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in .

Front Microbiol. 2018; 
Al Abdallah Qusai,Martin-Vicente Adela,Souza Ana Camila Oliveira,Ge Wenbo,Fortwendel Jarr
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摘要

RasA is a major regulator of fungal morphogenesis and virulence in . The proper localization of RasA to the plasma membrane is essential for the formation of invasive hyphae during infection. In yeast, the localization of Ras2p to the plasma membrane is orchestrated by several post-translational modifications (PTM) at the C-terminal CAAX box that are thought to occur in sequential order. These PTMs include: (1) CAAX motif farnesylation by the farnesyltransferase complex composed of Ram1p and Ram2p; (2) proteolysis of the -AAX residues by Rce1p or Ste24p; (3) methylation of the remaining prenylated cysteine residue by Ste14p, and; (4) palmitoylation at a single conserved cysteine residue mediated by the Erf2... More

关键词

Aspergillus,CAAX,Ras,cell wall,palmitoylation,prenyla