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TSO1 and MYB3R1 form a regulatory module to coordinate cell proliferation with differentiation in shoot and root.

Proc. Natl. Acad. Sci. U.S.A.. 2018; 
Wang Wanpeng,Sijacic Paja,Xu Pengbo,Lian Hongli,Liu Zhon
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摘要

Fundamental to plant and animal development is the regulated balance between cell proliferation and differentiation, a process intimately tied to cell cycle regulation. In , mutations in TSO1, whose animal homolog is LIN54, resulted in severe developmental abnormalities both in shoot and root, including shoot meristem fasciation and reduced root meristematic zone. The molecular mechanism that could explain the mutant phenotype is absent. Through a genetic screen, we identified 32 suppressors that map to the gene, encoding a conserved cell cycle regulator. Further analysis indicates that TSO1 transcriptionally represses , and the ectopic MYB3R1 activity mediates the mutant phenotype. Since ani... More

关键词

DREAM complex,MYB3R1,TSO1,cell cycle,meri