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Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors.

Cell Death Discov. 2018; 
BulatovEmil,SayarovaRegina,MingaleevaRimma,MiftakhovaRegina,GomzikovaMarina,IgnatyevYuri,PetukhovAlexey,DavidovichPavel,RizvanovAlbert,BarlevNickol
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Catalog Antibody Antibodies used were anti-p53 antibody [DO-1] (ab1101, Abcam), anti-mouse IgG–Peroxidase antibody (A4416, Sigma Aldrich), THE Beta Actin antibody [HRP] (A00730, GenScript). Get A Quote

摘要

Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment. Transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. We report here the biological evaluation of a novel Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis. Further, the impact of compounds on the p53 protein and expression of its target genes, including , , and was evaluated. Results obtained in this study provide further evidence in support of our prior data... More

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