凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching.

J. Virol.. 2019; 
JeevaSubbiah,MirSheema,VelasquezAdrain,WeathersBrandy A,LekaAljona,WuSharon,SevaranyAriga Tahmasian,MirMoha
Products/Services Used Details Operation
Catalog Antibody The rabbit anti -His tag antibody was from GenScript (Catalog #: A00174). Get A Quote

摘要

The hantavirus RNA-dependent RNA polymerase (RdRp) snatches 5' capped mRNA fragments from the host cell transcripts and uses them as primers to initiate transcription and replication of the viral genome in the cytoplasm of infected cells. Hantavirus nucleocapsid protein (N protein) binds to the 5' caps of host cell mRNA and protects them from the attack of cellular decapping machinery. N protein rescues long capped mRNA fragments in cellular P bodies that are later processed by an unknown mechanism to generate 10- to 14-nucleotide-long capped RNA primers with a 3' G residue. Hantavirus RdRp has an N-terminal endonuclease domain and a C-terminal uncharacterized domain that harbors a binding site for the N protei... More

关键词

cap snatching,hantavirus,negative-strand RNA virus,nucleoca