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EPO does not promote interaction between the erythropoietin and beta-common receptors.

Sci Rep. 2018; 
Cheung Tung Shing KS,, Broughton SE,, Nero TL,, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW,, Perkins AC, Dhagat U,.
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Recombinant Proteins EPO was purchased from Genscript (Z02975-50) and IL-3 + IL-3Rα was prepared as described in58.... EPO was purchased from Genscript (Z02975-50) for the AUC studies. Get A Quote

摘要

A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) is controversial. On one hand, studies have shown a functional link between EPOR and βc receptor in tissue protection while others have shown no involvement of the βc receptor in tissue repair. To date there is no biophysical evidence to confirm a direct association of the two receptors either in vitro or in vivo. We investigated the existence of an interaction between the extracellular regions of EPOR and the βc receptor in silico and in vitro (either in the presence or absence of EPO or EPO-derived peptide ARA290). Although a possible interaction between EPOR and βc was sugges... More

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