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Activating Killer-Cell Immunoglobulin-Like Receptors (Kir) And Their Cognate Hla Ligands Are Significantly Increased In Autism.

Brain Behav Immun.. 2012-10;  26(7):1122 - 7
Torres AR, Westover JB, Gibbons C, Johnson RC, Ward DC. Center for Persons with Disabilities, Utah State University, Logan, UT 84322-6804, USA.
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摘要

Killer-cell immunoglobulin-like receptor (KIR) proteins are expressed on natural killer (NK) cells and appear important in innate and adaptive immunity. There are about 14 KIR genes on chromosome 19q13.4, composed of those that inhibit and those that activate NK cell killing. Haplotypes have different combinations of these genes meaning that not all genes are present in a subject. There are two main classes of cognate human leukocyte antigen (HLA) ligands (HLA-Bw4 and HLA-C1/C2) that bind to the inhibitory/activating receptors. As a general rule, the inhibitory state is maintained except when virally infected or tumor cells are encountered; however, both increased activation and inhibition states have been asso... More

关键词

Killer-cell immunoglobulin-like receptor; KIR genes; KIR haplotypes; Human leukocyte antigen; HLA ligands; Leukocyte receptor complex; Autism; Immune dysfunction; Natural killer cells