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The Osteogenesis Effect and Underlying Mechanisms of Local Delivery of gAPN in Extraction Sockets of Beagle Dogs.

Int J Mol Sci. 2015; 
Hu H,, Pu Y,, Lu S,, Zhang K, Guo Y,, Lu H,, Li D,, Li X, Li Z, Wu Y,, Tang Z,.
Products/Services Used Details Operation
Cellular Analysis His-tagged gAPN was purified using GE Pharmacia AKTA Purifier 10 (Ramsey, MN, USA) followed by endotoxin removal (L00338, GenScript, Piscataway, NJ, USA) and Zeba Spin Desalting Columns (89893, Pierce, Rockford, IL, USA). Get A Quote

摘要

A plastic and biodegradable bone substitute consists of poly (L-lactic-co-glycolic) acid and 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use of globular adiponectin (gAPN) as an anabolic agent for tissue-engineered bone using this scaffold. A qualitative analysis of the bone regeneration process was carried out using μCT and histological analysis 12 weeks after implantation. CBCT (Cone Beam Computed Tomography) superimposition was used to characterise the effect of the different treatments on bone formation. In this study, we also explored adiponectin's (APN) influence on primary cultured human jaw bone marrow m... More

关键词

BMP2 (bone morphogenetic protein 2); adiponectin; beagle dog; dental material; mesenchymal stem cells