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Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.

Nat Commun. 2017; 
Xu Z, Xu L, Li W, Jin X, Song X, Chen X, Zhu J, Zhou S, Li Y, Zhang W, Dong X, Yang X, Liu F, Bai H, Chen Q, Su C.
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Cellular Analysis Measurement of serum LPS was performed using Toxin Sensor TM Chromogenic LAL Endotoxin Assay Kit (cat: L00350; GenScript, Piscataway, NJ, USA) per the manufacturer’s specifications. Get A Quote

摘要

The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifie... More

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