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Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.

Materials (Basel). 2019; 
Zhao J, Honda Y, Tanaka T, Hashimoto Y, Matsumoto N.
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Nucleic Acid Purification & Analysis … The LPS contents of the medical- and reagent-grade gelatin in Milli-Q water were measured utilizing a ToxinSensor TM Chromogenic LAL Endotoxin Assay Kit (L00350, GenScript USA Inc, Piscataway, NJ, USA) according to the manufacturer's instructions 23 … Get A Quote

摘要

Lipopolysaccharide (LPS) is a well-known strong inducer of inflammation. However, there is little information regarding how LPS-release behavior affects cellular senescence at the affected area. In this paper, we demonstrate that a vacuum-heating technique (dehydrothermal treatment) can be utilized to prepare an LPS sustained-release gelatin sponge (LS-G). LPS sustained release from gelatin leads to the long-term existence of senescent cells in critical-sized bone defects in rat calvaria. Three types of gelatin sponges were prepared in this study: a medical-grade gelatin sponge with extremely low LPS levels (MG), LS-G, and a LPS rapid-release gelatin sponge (LR-G). Histological (H-E) and immunohistochemical (CO... More

关键词

bone formation; cellular senescence; inflammation; lipopolysaccharide