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The Rosetteless gene controls development in the choanoflagellate S rosetta

Elife. 2015; 
Levin TC, Greaney AJ, Wetzel L, King N
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Catalog Antibody Three negative control treatments were analyzed in parallel: (1) 50 µg/ml BSA (from a 1.25 mg/ml stock in PBS); (2) 14 µl of pre-immune serum (equivalent to the volume of antibody added in the 50 µg/ml condition); and (3) 50 µg/ml of a control, rabbit polyclonal antibody (from a 1.25 mg/ml stock in PBS, #A01008, Genscript, Piscataway, NJ). Get A Quote

摘要

The origin of animal multicellularity may be reconstructed by comparing animals with one of their closest living relatives, the choanoflagellate Salpingoeca rosetta. Just as animals develop from a single cell-the zygote-multicellular rosettes of S. rosetta develop from a founding cell. To investigate rosette development, we established forward genetics in S. rosetta. We find that the rosette defect of one mutant, named Rosetteless, maps to a predicted C-type lectin, a class of signaling and adhesion genes required for the development and innate immunity in animals. Rosetteless protein is essential for rosette development and forms an extracellular layer that coats and connects the basal poles of each cell in ro... More

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