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An essential role for chloroplast heat shock protein 90 (Hsp90C) in protein import into chloroplasts.

Proc Natl Acad Sci U S A.. 2013-02;  110(8):3173 - 8
Inoue H, Li M, Schnell DJ. Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
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摘要

Chloroplast heat shock protein 90 (Hsp90C) represents a highly conserved subfamily of the Hsp90 family of molecular chaperones whose function has not been defined. We identified Hsp90C as a component that interacts with import intermediates of nuclear-encoded preproteins during posttranslational import into isolated chloroplasts. Hsp90C was specifically coprecipitated with a complex of protein import components, including Tic110, Tic40, Toc75, Tic22, and the stromal chaperones, Hsp93 and Hsp70. Radicicol, an inhibitor of Hsp90 ATPase activity, reversibly inhibited the import of a variety of preproteins during translocation across the inner envelope membrane, indicating that Hsp90C functions in membrane transloc... More

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