Genscript, NJ, USA). Amino acids 24 and 26 from the HPV-16 E7 sequence were changed to glycines to eliminate any residual pRb- binding effect of the E7 protein. ... ">

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Enhanced therapeutic effects conferred by an experimental DNA vaccine targeting human papillomavirus-induced tumors.

Hum Gene Ther.. 2013-09; 
MO Diniz, FAMO Cariri, LRMM Aps, LCS Ferreira. University of Sao Paulo, Microbiology, Av. Prof. Lineu Prestes, 1374, Cidade UniversitÁria, Av. Prof. Lineu Prestes, 1374, Sao Paulo, Sao Paulo, Brazil
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摘要

Human papillomavirus (HPV) infection is responsible for all cervical cancer cases, other anogenital cancers and head and neck tumors. The epidemiological relevance of HPV-induced tumors reinforces the need for the development of therapeutic anti-tumor vaccines. Clinical trials with different vaccine formulations, particularly DNA vaccines, have provided promising results but have still been unable to achieve the immunogenicity required for use in infected patients. In experimental conditions, anti-cancer HPV-specific vaccines induced E7-specific CD8+ T cells responses but did not confer full therapeutic anti-tumor protection in mice with transplanted HPV-expressing TC-1 cells, which are the most frequently used... More

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