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Protein Phosphatase 2A Isoforms Utilizing Aβ Scaffolds Regulate Differentiation through Control of Akt.

J Biol Chem.. 2013-09; 
Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS. Tufts U. School of Medicine ,Sackler School Graduate Biomedical Sciences, United States
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摘要

Protein phosphatase 2A (PP2A) regulates almost all cell signaling pathways. It consists of a scaffolding A subunit to which a catalytic C subunit and one of many regulatory B subunits bind. Of the more than 80 PP2A isoforms, 10% use Aβ as a scaffold. This study demonstrates isoform specific function of the A scaffold subunits. Polyomaviruses have shown the importance of phosphotyrosine, PI3K and p53 in transformation. Comparisons of polyoma small T (PyST) and SV40 small T (SVST) implicate Aβ in control of differentiation. Knockdown of Aβ enhanced differentiation. Akt signaling regulates differentiation; its activation or inhibition respectively promoted or blocked. Aβ binds Akt. Enhancement ... More

关键词

Akt; Differentiation; PI 3-kinase (PI3K); PP2A; Protein kinases; Protein phosphatase; SV40; polyomavirus