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Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells.

Stem Cells.. 2013-10; 
Q Gan, A Lee, R Suzuki, T Yamagami, A Stokes, Bao Chau Nguyen, David Pleasure, Junjiang Wang, Hong-Wu Chen, Chengji J. Zhou. Institute for Pediatric Regenerative Medicine, University of California at Davis, School of Medicine, 2425 Stockton Blvd., Room-602B, SHCNC, Sacramento, CA 95817, USA
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摘要

The Wnt/ß-catenin pathway is a critical stem cell regulator and plays important roles in neuroepithelial cells during early gestation. However, the role of Wnt/ß-catenin signaling in radial glia, a major neural stem cell population expanded by mid-gestation, remains poorly understood. This study shows that genetic ablation of ß-catenin with hGFAP-Cre mice inhibits neocortical formation by disrupting radial glial development. Reduced radial glia and intermediate progenitors are found in the ß-catenin-deficient neocortex during late gestation. Increased apoptosis and divergent localization of radial glia in the subventricular zone are also observed in the mutant neocortex. In vivo and in v... More

关键词

Neural stem cells; Radial glia; Wnt/ß-catenin; Pax6; Proliferation; Neurogenesis