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TRIM14 Is a Key Regulator of the Type I IFN Response during Infection

J Immunol. 2020; 
Caitlyn T Hoffpauir, Samantha L Bell, Kelsi O West, Tao Jing, Allison R Wagner, Sylvia Torres-Odio, Jeffery S Cox, A Phillip West, Pingwei Li, Kristin L Patrick, Robert O Watson
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摘要

Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune signaling and gene expression during bacterial infection remains largely unknown. Because is an activator of cGAS-dependent cytosolic DNA sensing, we set out to investigate a role for TRIM proteins in regulating macrophage responses to In this study, we demonstrate that TRIM14, a noncanonical TRIM that lacks an E3 ubiquitin ligase RING domain, is a critical negative regulator of the type I IFN response in macrophages. We show that TRIM14 interacts with both cGAS an... More

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