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Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

Front Oncol. 2020; 
Tingjian Zu, Jie Wen, Lin Xu, Hui Li, Jun Mi, Hui Li, Cord Brakebusch, David E Fisher, Xunwei Wu
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Proteins, Expression, Isolation and Analysis … Cat. No. Z03034-10, GenScript, Nanjing) at 100 ng/kg/day/mouse (3 mice per group). Each injection contained 0.5 million UACC62 melanoma cells and 0.5 million HDFs, and each mouse received injections at 4 different sites … Get A Quote

摘要

The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy. Activating transcription factor 3 (ATF3) plays a crucial role in regulating tumorigenesis and development, but whether the expression of ATF3 in human dermal fibroblasts (HDFs) can affect melanoma development hasn't been studied. Our results show that ATF3 expression is downregulated in stromal cells of human melanoma. HDFs expressing high levels of ATF3 suppressed the growth and migration of melanoma cells in association with downregulation of different cytokines including IL-6 . , HDFs with high ATF3 expression reduced tumor formation. ... More

关键词

activating transcription factor 3, fibroblasts, interleukin 6, melanoma, stromal cells