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Increased SERPINA3 Level Is Associated with Ulcerative Colitis

Diagnostics (Basel). 2021-12; 
Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen
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Recombinant Proteins . TNFα (10 ng/mL, Z01001, GenScript Biotech, Nanjing, China) was used in cell culture with HT29 cells for 12 h to mimic an inflammatory background Get A Quote

摘要

Ulcerative colitis (UC) is a recurrent, chronic intestinal disease that is currently incurable. Its pathogenesis remains to be further understood. Therefore, seeking new biomarkers and potential drug targets is urgent for the effective treatment of UC. In this study, the gene expression profile GSE38713 was obtained from the GEO (Gene Expression Omnibus) database. Data normalisation and screening of the differentially expressed genes (DEGs) were conducted using R software, and gene ontology (GO) enrichment was performed using Metascape online tools. The PubMed database was used to screen new genes that have not been reported, and SERPINA3 was selected. The correlation between SERPINA3 and other inflammatory fac... More

关键词

SERPINA3; biomarker; ulcerative colitis.