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Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period

Front Immunol. 2021-10; 
Wen-Heng Ji, Dan-Dan Li, Dan-Ping Wei, Ai-Qin Gu, Ying Yang, Jing-Pian Peng
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Gene Synthesis … 1 × 10 5 cells/well and incubated with anti-CYP26A1 antibody (Ab) (1:25, Invitrogen, PA5-24602) or control IgG (1:50, Genscript, A01008) for … According to the sequencing results, the differentially expressed genes (DEGs) in WT and KO groups with two biological replicates were … Get A Quote

摘要

Uterine M1/M2 macrophages activation states undergo dynamic changes throughout pregnancy, and inappropriate macrophages polarization can cause adverse pregnancy outcomes, especially during the peri-implantation period. Our previous studies have confirmed that Cytochrome P450 26A1 (CYP26A1) can affect embryo implantation by regulating uterine NK cells and DCs. The aim of this study was to investigate whether CYP26A1 regulates the polarization of uterine macrophages in early pregnancy. Here, we observed that was significantly upregulated in M1 as compared with M2 of uterine macrophages, Raw264.7 and iBMDM. Knockdown of CYP26A1 in mice uterine significantly decreased the number of embryo implantation sites and th... More

关键词

CYP26A1, embryo implantation, inflammatory response, peri-implantation period, uterine macrophages polarization (M1/M2)