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Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Front Mol Biosci. 2021-09; 
Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou
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Gene Synthesis … Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were analyzed using the “clusterprofiler,” “ggplot2 … no. M00664, GenScript) for electrophoresis and transferred to polyvinylidene fluoride (PVDF) membranes … Get A Quote

摘要

Despite considerable efforts to improve treatment modalities for cholangiocarcinoma, a common form of malignant tumor, its long-term survival rate remains poor. Hydroxychloroquine (HCQ) is a 4-aminoquinoline derivative antimalarial drug that has antimalarial and autophagy inhibition effects and exhibits comprehensive therapeutic effects on various cancers. In this study, we aimed to explore the anticancer potential and the underlying molecular mechanism of HCQ in cholangiocarcinoma treatment and . Autophagy-related genes (ARGs) were obtained from the Human Autophagy Database and Molecular Signatures Database, and the expression profiles of ARGs were downloaded from the database of The Cancer Genome Atlas. Dif... More

关键词

HCQ, ROS, TCGA, autophagy, cholangiocarcinoma