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Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease

Clin Transl Med. 2021-12; 
Jeong Seok Yu, Gi Soo Youn, Jieun Choi, Chang-Ho Kim, Byung Yong Kim, Seung-Jo Yang, Je Hee Lee, Tae-Sik Park, Byoung Kook Kim, Yeon Bee Kim, Seong Woon Roh, Byeong Hyun Min, Hee Jin Park, Sang Jun Yoon, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Hotaik Sung, Sang Hak Han, Ki Tae Suk, Do Yup Lee
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摘要

background: Although microbioa-based therapies have shown putative effects on the treatment of non-alcoholic fatty liver disease (NAFLD), it is not clear how microbiota-derived metabolites contribute to the prevention of NAFLD. We explored the metabolomic signature of Lactobacillus lactis and Pediococcus pentosaceus in NAFLD mice and its association in NAFLD patients. methods: We used Western diet-induced NAFLD mice, and L. lactis and P. pentosaceus were administered to animals in the drinking water at a concentration of 10 CFU/g for 8 weeks. NAFLD severity was determined based on liver/body weight, pathology and biochemistry markers. Caecal samples were collected for the metagenomics by 16S rRNA sequencing. M... More

关键词

gut-liver axis, indole, metabolites, microbiome, non-alcoholic fatty liver disease