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The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Mol Cell Endocrinol. 2021-06; 
Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin
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Recombinant Proteins … FBS; SH30084.03, HyClone, USA) at 37°C with 5% CO 2 . Immunofluorescence staining for α-SMA was performed to identify the isolated VSMCs. All cells at passages 3-8 were used in subsequent experiments. VSMCs were treated with PDGF-BB (Z03096, GenScript, China) at … Get A Quote

摘要

The phenotypic change of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic form is a key player in atherogenic processes. Homeobox A5 (HOXA5), a transcription factor of the homeobox gene family, has been shown to regulate cell differentiation and morphogenesis. The present study was designed to clarify the involvement of HOXA5 in VSMC phenotypic transition in carotid atherosclerosis (CAS). Activated VSMCs in vitro and ApoE mice in vivo were employed to determine HOXA5's function. Results showed that both the mRNA and protein expression levels of HOXA5 were decreased in platelet-derived growth factor-BB (PDGF-BB)-induced VSMCs. Overexpression of HOXA5 suppressed VSMC conversion from a contra... More

关键词

Carotid atherosclerosis, Homeobox A5, Peroxisome proliferator-activated receptor γ, Vascular smooth muscle cells