凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach

Pharmaceutics. 2022-09; 
Alessandro Giuliani, Stefano Fais
Products/Services Used Details Operation
… (residues 1-366) were subcloned into the pcDNA 3.1 vector with a Flag-tag, SPOP MATH (… GST or GST-SPOP MATH proteins bound to GST magnetic beads (GenScript, L00327) were …

摘要

The molecular revolution could lead drug discovery from chance observation to the rational design of new classes of drugs that could simultaneously be more effective and less toxic. Unfortunately, we are witnessing some failure in this sense, and the causes of the crisis involve a wide range of epistemological and scientific aspects. In pharmacology, one key point is the crisis of the paradigm the "magic bullet", which is to design therapies based on specific molecular targets. Drug repurposing is one of the proposed ways out of the crisis and is based on the off-target effects of known drugs. Here, we propose the microenvironment as the ideal place to direct the off-targeting of known drugs. While it has been ... More

关键词

diseases, drugs, microenvironment, off-targeting, proton exchangers inhibitors, proton pump inhibitors