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β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Behav Brain Res. 2022-04; 
Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen
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Proteins, Expression, Isolation and Analysis … gels (GenScript Biotech, M00656, China) were used for electrophoresis and then transferred … 1:1 and evenly poured on the PVDF, and then developed in the imager. The blots shown in … Get A Quote

摘要

Autism is a complex neurodevelopmental disease that may be caused by genetic and environmental factors, that are incompletely understood. Overactivation of dopaminergic receptors can lead to autistic-like behavior. β-arrestin2 (Arrb2) is a scaffolding protein of the arrestin family, which function as cytosolic multifunctional adapter proteins that activate cell signal transduction and mediate the signal termination and endocytosis of G-protein-coupled receptors (GPCRs) complexes. In this study, we established an Arrb2 knockout (Arrb2) mouse to explore the biological function of Arrb2 in autistic-like behavior caused by abnormality in the dopaminergic system. We found that Arrb2 mice did not exhibit the autisti... More

关键词

Arrb2, Autistic-like behavior, Dopamine receptor, ERK signaling pathway