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A novel delayed lateral flow immunoassay for enhanced detection of SARS-CoV-2 spike antigen

Mikrochim Acta. 2022-09; 
Pawanrat Srithong, Sudkate Chaiyo, Ekawat Pasomsub, Sirirat Rengpipat, Orawon Chailapakul, Narong Praphairaksit
Products/Services Used Details Operation
Catalog Antibody … A02046) were purchased from GenScript USA, Inc (NJ, USA). Sodium carbonate anhydrous (Na 2 CO 3 ) and sodium hydroxide (NaOH) were obtained from Merck Millipore (Billerica, … Get A Quote

摘要

A new detection strategy was developed to improve the sensitivity of a lateral flow immunoassay platform utilizing a delayed hydrophobic barrier fabricated with trimethylsilyl cellulose (TMSC). The SARS-CoV-2 spike receptor-binding domain (SARS-CoV-2 SP RBD) antigen was chosen as a model analyte to demonstrate the superior detectability of this scheme. The novel device consists of 2 separate layers, so-called delayed lateral flow immunoassay (d-LFIA). The upper layer is intended for the analyte or sample flow path, where the test solution flows freely straight to the detection zone to bind with the primary antibody. The lower layer, located just underneath, is designed for the SARS-CoV-2 spike receptor-binding ... More

关键词

COVID-19, Colorimetric detection, Lateral flow immunoassay, SARS-CoV-2, Trimethylsilyl cellulose