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The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology

Heliyon. 2022-10; 
Xiang Lin, Li Xu, Huicheng Tan, Xinyi Zhang, Huan Shao, Li Yao, Xuan Huang
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Proteins, Expression, Isolation and Analysis … An equal amount of protein from each experimental group was separated on 4–20% SurePAGE (Genscript, M00656) and transferred onto a 0.45-μm PVDF membrane (Millipore, … Get A Quote

摘要

unassigned: Resistance to chemotherapeutic drugs, such as oxaliplatin (OXA), can lead to unsatisfactory chemotherapy results during the treatment of advanced colorectal cancer (CRC). Therefore, we investigated the potential targets and mechanisms of Gegen Qinlian Decoction (GQD) against OXA-resistant CRC through network pharmacology and performed molecular docking and experimental verification. unassigned: We collected potential compounds, targets, and related disease genes from public databases. The pharmacology model of the compound-target-pathway network and protein-protein interaction (PPI) network were established. The potential active components and mechanisms underlying GQD reversing OXA-resistant CRC we... More

关键词

ABC transporter, Chemotherapy resistance, Colorectal cancer, Gegen qinlian decoction, Network pharmacology