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N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation

Pharmacol Res. 2022-10; 
Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu
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Recombinant Proteins … In separate cultures, bone marrow cells were cultured with Flt3L (Genscript, Cat. Z03227, … to CL), the Key Program of Frontier Science, CAS (QYZDJ-SSW-SLH033 to CL), the National … Get A Quote

摘要

Psoriasis is an incurable autoimmune disease that affects 2-3% of the world's population. Limited understanding of its pathogenesis hinders the development of therapies for the disease. Herein, we reported that N-acylethanolamine acid amidase (NAAA), a cysteine enzyme that catalyzes the hydrolysis of fatty acid ethanolamides (FAEs), was upregulated in psoriasis patients and imiquimod (IMQ)-induced mouse model of psoriasis. The upregulated NAAA contributes to the progression of psoriasis via enhancing dendritic cell (DCs) maturation. Transgenic expression of NAAA in mice accelerated the development of psoriasis, whereas genetic ablation of NAAA or local administration of NAAA inhibitor F96 ameliorated psoriasis.... More

关键词

Dendritic cells (DCs), N-acylethanolamine acid amidase (NAAA), Palmitoylethanolamide (PEA), Peroxisome proliferator activated receptor α (PPARα), Psoriasis, Sirtuin 1 (SIRT1)