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Zika virus baculovirus-expressed envelope protein elicited humoral and cellular immunity in immunocompetent mice

Sci Rep. 2022-01; 
Minna Shin, Kiju Kim, Hyo-Ji Lee, Rangyeon Lee, Yu-Jin Jung, Jeongho Park, Tae-Wook Hahn
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摘要

Zika virus (ZIKV) is a mosquito-borne virus that has a high risk of inducing Guillain-Barré syndrome and microcephaly in newborns. Because vaccination is considered the most effective strategy against ZIKV infection, we designed a recombinant vaccine utilizing the baculovirus expression system with two strains of ZIKV envelope protein (MR766, Env_M; ZBRX6, Env_Z). Animals inoculated with Env_M and Env_Z produced ZIKV-specific antibodies and secreted effector cytokines such as interferon-γ, tumor necrosis factor-α, and interleukin-12. Moreover, the progeny of immunized females had detectable maternal antibodies that protected them against two ZIKV strains (MR766 and PRVABC59) and a Dengue virus strain. We pro... More

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