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Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Neurotox Res. 2022-09; 
Shashank Kumar Maurya, Rajnikant Mishra
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Catalog Antibody … The anti-β-actin (anti-mouse, A00702, GenScript, USA) was used to evaluate the loading controls. Signals were detected by the substrate for enhanced chemiluminescence (ECL) (… Get A Quote

摘要

The Pax6 binds to promoter sequence elements of genes involved in immunological surveillance and interacts with Iba1, p53, Ras-GAP, and Sparc in the brain of mice. The Pax6 also affects the expression pattern of genes involved in neurogenesis and neurodegeneration. However, the expression and association of Pax6 in the brain under immunologically challenged conditions are still elusive. Therefore, it has been intended to analyze the association of Pax6 in the immunity of the brain using the immune-challenged Dalton's lymphoma (DL) mice model. The expressions of Pax6, Iba1, and Tmem119 decreased, but expressions of Ifn-γ, Tnf-α, Bdnf, and Tgf-β increased in the brain of immune-challenged mice as compared to t... More

关键词

Brain immunity, Dalton’s lymphoma, Microglia, Neuroinflammation, Pax6