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Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells

Front Pharmacol. 2022-07; 
Yichen Wu, Min Chen, Zilong Chen, Jiangcheng Shu, Luoying Zhang, Jiong Hu, Hongjun Yu, Kai Huang, Minglu Liang
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Recombinant Proteins … RASMCs were then cultured with FBS-free DMEM for 24 h and treated with PBS as a control or 20 ng/ml PDGF-BB (GenScript, Z03179) with or without adding different concentrations of … Get A Quote

摘要

The abnormal neointima formation caused by the phenotypic switching of vascular smooth cells (VSMCs) into a synthetic state plays a key role in the pathogenesis of various vascular diseases, including atherosclerosis and postangioplasty restenosis. Theaflavin-3,3'-digallate (TF3) in black tea has been reported to exert antiinflammatory and anticancer effects, but its role in neointima formation remains unclear. Here, we delineated a remarkable effect of TF3 in suppressing neointima formation of VSMCs as well as the ability of primary rat aortic smooth cells (RASMCs) to proliferate and migrate . Further study confirmed that the effects of TF3 on PDGF-BB-induced RASMCs were due to reduced phosphorylation of PDGF... More

关键词

PDGFRβ signaling pathway, TF3, neointima formation, phenotypic switching, vascular smooth muscle cells