凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses

J Biol Chem. 2022-06; 
Evert J Loef, Hilary M Sheppard, Nigel P Birch, P Rod Dunbar
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … A00702-100, GenScript, Piscataway, New Jersey, USA) antibodies. Western blots were visualized using 680RD donkey anti-mouse (Li-Cor Biosciences, Lincoln, NE, USA) and 800 CW … Get A Quote

摘要

Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted by the plasminogen activators. In the circulation, high levels of α2-antiplasmin rapidly and efficiently inhibit plasmin activity. Certain myeloid immune cells have been shown to bind plasmin and plasminogen on their cell surface via proteins that bind to the plasmin(ogen) kringle domains. Our earlier work showed that T cells can activate plasmin but that they do not themselves express plasminogen. Here, we demonstrate that T cells express several known plasminogen receptors and that they bind plasminogen on their cell s... More

关键词

T-cell, T-cell biology, cell migration, cell motility, chemokine, chemotaxis, microscopy, plasmin, plasminogen, plasminogen regulation