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Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers

Cell Rep. 2022-08; 
Yuqiu Xu, Zhuang Wei, Mei Feng, Dexiang Zhu, Shenglin Mei, Zhongen Wu, Qingyang Feng, Wenju Chang, Meiling Ji, Chenglong Liu, Yuanyuan Zhu, Lian Shen, Fan Yang, Yijiao Chen, Yuxiong Feng, Jianmin Xu, Di Zhu
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Recombinant Proteins … Besides, after treatment with SDF-1 (Z03306-5, Genscript, USA) in time and concentration dependent manner, and with hsBCL9CT-24, Nobiletin (N1311, APE×BIO, USA), GDC-0068 (… Get A Quote

摘要

More than 40% of patients with late-stage colorectal cancer (CRC) develop liver metastasis (LM). Which immune cells play important roles in CRC-LM and contribute to the difference between left-sided CRC (LCC) and right-sided CRC (RCC) remain unclear. By single-cell RNA sequencing (scRNA-seq), we not only find that activated B cells are significantly depleted in CRC with LM, but also find a subtype of B cells developed from activated B cells, namely immature plasma cell population alpha (iMPA), highly correlated with metastasis. Mechanistically, inhibition of the Wnt and transforming growth factor β (TGF-β) pathways in cancer cell promotes activated B cell migration via the SDF-1-CXCR4 axis. This study reveals... More

关键词

CP: Cancer, SDF-1-CXCR4, Wnt signaling, activated B cells, colorectal cancer, liver metastasis, scRNA-seq, tumor immune microenvironment