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Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway

Vet Microbiol. 2021-05; 
Xingchen Wu, Zhenyu Wang, Dan Qiao, Yu Yuan, Cong Han, Nan Yang, Ruizhen Li, Qian Du, Dewen Tong, Yong Huang
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Catalog Antibody … bovine serum (13011-8611; Tianhang Biotechnology, Huzhou, China … Abcepta), anti-β-actin (A00702; Genscript, Nanjing, China … antibody (BM4389; Wuhan Boster Biotech, Wuhan, China … Get A Quote

摘要

Porcine circovirus 2 (PCV2) has been proved to increase the risk of other pathogens infection via immunosuppression. Although the co-infection of PCV2 and porcine parvovirus (PPV) is commonly observed in worldwide, the relative immune mechanisms promoting PPV infection in PCV2-infected piglets are currently unknown. Herein, we found that PCV2 infection suppressed IFN-β expression and promoted PPV infection in the piglets. Consistent with this finding, we confirmed that PCV2 infection significantly inhibited the induction of IFN-β to promote PPV replication in cell level. Furthermore, PCV2 infection attenuated the K63-linked ubiquitination of STING induced by PPV, blocked the formation of complex of STING, TBK... More

关键词

Porcine circovirus type 2 (PCV2), Stimulator of interferon genes (STING), Type I interferon beta (IFN-β), p38-MAPK signaling