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Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation

EMBO Rep. 2021-11; 
Qisheng Zuo, Jin Jing, Jing Zhou, Yani Zhang, Wanhong Wei, Guohong Chen, Bichun Li
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Proteins, Expression, Isolation and Analysis A 12% Sure PAGE prefabricated plastic E(M01210C,GenScript,Nanjing,China)gel was used to perform electrophoresis Get A Quote

摘要

The unique characteristics of chicken primordial germ cells (PGCs) provide potential strategies for transgenic animal generation; however, insufficient PGC availability has limited their application. Regulation of bone morphogenic protein 4 (BMP4), a crucial factor for PGCs formation, may provide new strategies for PGC generation. We here identify a long noncoding RNA (lncRNA) that targets BMP4 (LncBMP4). LncBMP4 has similar functions as BMP4, in that it facilitates the formation and migration of PGCs. LncBMP4 promotes BMP4 expression by adsorbing the miRNA gga-mir-12211, thus reducing its inhibitory effect on BMP4 expression. In addition, the small peptide EPC5 encoded by LncBMP4 promotes the transcription of ... More

关键词

BMP4, LncRNA, chicken, m6A, primordial germ cells